Adam and Eve, designed diversity, and allele frequencies

Allele Frequencies and Genotype Frequencies

The Doomsday Argument Adam & Eve, UN++, and Quantum Joe

The Doomsday argument purports to show that the risk of the human species going extinct soon has been systematically underestimated. This argument has something in common with controversial forms of reasoning in other areas, including: game theoretic problems with imperfect recall, the methodology of cosmology, the epistemology of indexical belief, and the debate over so-called fine-tuning argu...

A Comparison between Adam-Eve GA and Traditional GAs

GAs, which are powerful stochastic optimization techniques are perhaps the most widely known types of evolutionary algorithms. In this paper the Adam-Eve (Like) GA has been considered and its performance has been studied. The basic idea of GAs has been taken from nature; therefore it is reasonable if we expect an improvement in our model of GA, because it is much closer to the evolution of orga...

Estimating Allele Frequencies and Inbreeding Coefficients in K-Allele Models

Some of the methods of estimation of allele frequencies and inbreeding coefficients in a K-allele model are examined. A result that has long been assumed to be true is proved. That is, in the presence of inbreeding, the maximum likelihood estimators of the allele frequencies and of the inbreeding coefficient f do not in general equal their observed (or sample) values (except when K 1⁄4 2). A le...

Allele Frequencies of HLA-A, B and DRB1 among People of Fars Ethnicity Living in Tehran

Background: Human leukocyte antigens (HLA) are polymorphic cell surface proteins. Distribution of HLA alleles vary among different racial and ethnic populations in unrelated stem cell registries. Determination of HLA allele frequencies in different ethnic groups is useful for population genetic analyses. Materials and Methods: Based on data available from the Iranian Stem Cell Donor Registry...